Diane E. Griffin

  • Viral infections.- Mechanisms and importance of apoptosis during reovirus infections.-Poliovirus, pathogenesis of poliomyelitis and apoptosis.- Neuronal Cell Death in Alphavirus Encephalomyelitis.- HSV-Induced Apoptosis in Herpes Encephalitis.- The role of apoptosis in defense against baculovirus infection in insects.- Bacterial infections.- The role of host cell death in Salmonella infections.- Role of macrophage apoptosis in Yersinia pathogenesis.- Parasitic infections.- Entamoeba histolytica activates host cell caspases during contact-dependent cell killing.- Interactions between malaria and mosquitoes: the role of apoptosis in parasite establishment and vector response to infection.- Apoptosis and its modulation during infection with Toxoplasma gondii: Molecular mechanisms and role in pathogenesis.- Immune responses.- Modulation of the immune response in the nervous system by rabies virus.- Apoptotic cells at the crossroads of tolerance and immunity.- Subject index

  • Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease. Where vaccine has been effectively delivered, endemic measles virus transmission has been eliminated. However, difficulties in vaccine delivery, lack of health care support and objection to vaccination in some communities continue to result in nearly 40 million cases and over 300,000 deaths per year from measles.
    By itself measles virus infection has and still provides some of the most interesting phenomena in biology. Following infection of dendritic cells, measles virus causes a profound suppression of the host's immune response that lasts a number of months after apparent recovery from infection. Indeed, measles virus was the first virus to be associated with immunosuppression with many of the manifestations to be observed one hundred years later with HIV infection. Measles is also associated with development of both post-infectious encephalomyelitis, an autoimmune demyelinating disease, and subacute sclerosing panencephalitis, a slowly progressive neurodegenerative disorder. How measles virus infects cells, spreads to various tissues and causes disease, as well as the role of the immune response, generation of new vaccines, and use as a vector for gene delivery are topics covered in these two volumes.